Necroptosis: Molecular Signalling and Translational Implications

Necroptosis is a form of programmed Network Table necrosis whose molecular players are partially shared with apoptotic cell death.Here we summarize what is known about molecular signalling of necroptosis, particularly focusing Animaniacs on fine tuning of FLIP and IAP proteins in the apoptosis/necroptosis balance.We also emphasize necroptosis involvement in physiological and pathological conditions, particularly in the regulation of immune homeostasis.